Can follicular Emmprin and BMP 4 levels predict ICSI outcome?

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TAKMAZ Ö., Yozgatli D., Ozaltin S., ÖZBAŞLI E., Kocyigit Y., Kuran S. B., ...Daha Fazla

Journal of assisted reproduction and genetics, cilt.36, sa.6, ss.1127-1133, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s10815-019-01459-0
  • Dergi Adı: Journal of assisted reproduction and genetics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1127-1133
  • Anahtar Kelimeler: Basigin, BMP 4, Emmprin, Follicular fluid, Intracytoplasmic sperm injection, In vitro fertilization, MORPHOGENETIC PROTEIN 4, MATRIX METALLOPROTEINASE INDUCER, IMMUNOGLOBULIN SUPERFAMILY, IN-VITRO, BASIGIN, EXPRESSION, CELL, MEMBER, OVARY, HETERODIMERS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

PurposeTo evaluate the relationship of clinical pregnancy rates with bone morphogenetic proteins 2-4-7 (BMP 2, 4, 7), growth differentiation factor 9 (GDF 9), and Emmprin levels in follicular fluid of intracytoplasmic sperm injection patients.MethodsFollicular fluid of 77 patients who underwent ICSI procedure was collected during the oocyte retrieval procedure. And follicular fluid levels of BMP 2, BMP 4, BMP 7, GDF 9, and Emmprin (Basigin) were measured and compared for clinical pregnancy rates.ResultsFollicular levels of BMP 4 was significantly higher whereas Emmprin levels were lower in patients who had achieved clinically diagnosed pregnancy compared with those who did not achieve clinical pregnancy after ICSI procedure (P=0.007 and P=0.035, respectively). BMP 2, BMP 7, and GDF 9 levels were comparable for both groups.ConclusionClinical pregnancy rates after ICSI may be associated with follicular fluid levels of Emmprin and BMP 4. Follicular levels of Emmprin and BMP 4 can be used as a marker (as markers for predicting ICSI outcomes) for a better ICSI outcome.