Can follicular Emmprin and BMP 4 levels predict ICSI outcome?

Takmaz Ö. , Yozgatli D., Ozaltin S. , Ozbasli E. , Kocyigit Y., Kuran S., ...More

Journal of assisted reproduction and genetics, vol.36, no.6, pp.1127-1133, 2019 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1007/s10815-019-01459-0
  • Title of Journal : Journal of assisted reproduction and genetics
  • Page Numbers: pp.1127-1133


PurposeTo evaluate the relationship of clinical pregnancy rates with bone morphogenetic proteins 2-4-7 (BMP 2, 4, 7), growth differentiation factor 9 (GDF 9), and Emmprin levels in follicular fluid of intracytoplasmic sperm injection patients.MethodsFollicular fluid of 77 patients who underwent ICSI procedure was collected during the oocyte retrieval procedure. And follicular fluid levels of BMP 2, BMP 4, BMP 7, GDF 9, and Emmprin (Basigin) were measured and compared for clinical pregnancy rates.ResultsFollicular levels of BMP 4 was significantly higher whereas Emmprin levels were lower in patients who had achieved clinically diagnosed pregnancy compared with those who did not achieve clinical pregnancy after ICSI procedure (P=0.007 and P=0.035, respectively). BMP 2, BMP 7, and GDF 9 levels were comparable for both groups.ConclusionClinical pregnancy rates after ICSI may be associated with follicular fluid levels of Emmprin and BMP 4. Follicular levels of Emmprin and BMP 4 can be used as a marker (as markers for predicting ICSI outcomes) for a better ICSI outcome.