Role of ATP-dependent K channels in the effects of erythropoietin in renal ischaemia injury


Yilmaz T. U. , Yazihan N., Dalgic A., Kaya E. E. , Salman B., Kocak M., ...Daha Fazla

INDIAN JOURNAL OF MEDICAL RESEARCH, cilt.141, ss.807-815, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 141
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0971-5916.160713
  • Dergi Adı: INDIAN JOURNAL OF MEDICAL RESEARCH
  • Sayfa Sayıları: ss.807-815

Özet

Background & objectives: Erythropoietin (EPO) has cytoprotective and anti-apoptotic effects in pathological conditions, including hypoxia and ischaemia-reperfusion injury. One of the targets to protect against injury is ATP-dependent potassium (KATP) channels. These channels could be involved in EPO induced ischaemic preconditoning like a protective effect. We evaluated the cell cytoprotective effects of EPO in relation to KATP channel activation in the renal tubular cell culture model under hypoxic/normoxic conditions.