Renal iskemi hasarında eritropoietinin koruyucu etkisinde ATP bağımlı K kanallarının katılımı HIF 1 mRNA ekspresyonlarına etkisi

YILMAZ T. U., YAZIHAN N., SALMAN B., ERMİŞ E., DALGIÇ A.

5. Cerrahi Araştırma Kongresi, Türkiye, 10 - 12 Aralık 2009, cilt.141, ss.807, (Tam Metin Bildiri) identifier identifier identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 141
  • Doi Numarası: 10.4103/0971-5916.160713
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.807
  • Anahtar Kelimeler: Diazoxide, erythropoietin, glinbenclamide, hypoxia inducible factor-1 alpha, KATP channels, REPERFUSION INJURY, ISCHEMIA/REPERFUSION INJURY, SIGNALING PATHWAYS, MECHANISMS, KIDNEY, CARDIOPROTECTION, INFLAMMATION, PROTECTS, CELLS, HEART
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background & objectives: Erythropoietin (EPO) has cytoprotective and anti-apoptotic effects in pathological conditions, including hypoxia and ischaemia-reperfusion injury. One of the targets to protect against injury is ATP-dependent potassium (KATP) channels. These channels could be involved in EPO induced ischaemic preconditoning like a protective effect. We evaluated the cell cytoprotective effects of EPO in relation to KATP channel activation in the renal tubular cell culture model under hypoxic/normoxic conditions.