Inflammatory <SUP>68</SUP>Ga FAPI-46 Uptake Mimicking a Sister Mary Joseph's Nodule in a Case of Gastric Signet Ring Cell Carcinoma
CLINICAL NUCLEAR MEDICINE, vol.50, no.12, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 50 Issue: 12
- Publication Date: 2025
- Doi Number: 10.1097/rlu.0000000000005971
- Journal Name: CLINICAL NUCLEAR MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Acibadem Mehmet Ali Aydinlar University Affiliated: Yes
Abstract
Fibroblast activation protein (FAP) is a type II transmembrane protease expressed in cancer-associated fibroblasts (CAF) that constitute a part of the tumor stroma and influence the tumor microenvironment. Although FAP is not expected to be physiologically expressed in noncancer-associated cells, it can be observed in wound healing, arthritis, atherosclerotic plaques, and fibrosis. In this case, we would like to present early-stage 68Ga FAPI-46 PET/CT inflammation findings at the trocar entry site mimicking the Sister Mary Joseph's nodule in a patient diagnosed with gastric signet ring cell carcinoma.