Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors

BOZKURT, SÜHEYLA; DAĞÇINAR, ADNAN; TANRIKULU, BAHATTİN; Comunoglu, N.; Meydan, B.; ÖZEK, MEMET; Oz, B.

doi:10.1007/s00381-017-3633-5

Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors

BOZKURT S., DAĞÇINAR A., TANRIKULU B., Comunoglu N., Meydan B. C., ÖZEK Ö. M. M., ...Daha Fazla

CHILDS NERVOUS SYSTEM, cilt.34, sa.1, ss.107-116, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 34 Sayı: 1
Basım Tarihi: 2018
Doi Numarası: 10.1007/s00381-017-3633-5
Dergi Adı: CHILDS NERVOUS SYSTEM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.107-116
Anahtar Kelimeler: ATRX, p53, Histomorphology, BRAF V600E, INTRINSIC PONTINE GLIOMAS, THERAPEUTIC IMPLICATIONS, GLIONEURONAL TUMORS, GENETIC ALTERATIONS, K27M MUTATION, HISTONE H3.3, BRAF V600E, GLIOBLASTOMA, H3F3A, SUBGROUPS
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Pediatric high-grade gliomas (pHGGs) constitute almost 15% of all childhood brain tumors. Recurrent mutations such as H3K27M mutation in H3F3A and HIST1H3B genes encoding histone H3 and its variants were identified in approximately 30% of pediatric glioblastomas. This study aimed to ascertain the morphological and molecular characteristics of pHGGs with H3K27M mutation.