Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors


Bozkurt S. U. , Dagcinar A., Tanrikulu B. , Comunoglu N., Meydan B. C. , Ozek M. , ...More

CHILDS NERVOUS SYSTEM, vol.34, no.1, pp.107-116, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1007/s00381-017-3633-5
  • Title of Journal : CHILDS NERVOUS SYSTEM
  • Page Numbers: pp.107-116

Abstract

Pediatric high-grade gliomas (pHGGs) constitute almost 15% of all childhood brain tumors. Recurrent mutations such as H3K27M mutation in H3F3A and HIST1H3B genes encoding histone H3 and its variants were identified in approximately 30% of pediatric glioblastomas. This study aimed to ascertain the morphological and molecular characteristics of pHGGs with H3K27M mutation.