Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors


Bozkurt S. U. , Dagcinar A., Tanrikulu B. , Comunoglu N., Meydan B. C. , Ozek M. , et al.

CHILDS NERVOUS SYSTEM, cilt.34, ss.107-116, 2018 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 34 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s00381-017-3633-5
  • Dergi Adı: CHILDS NERVOUS SYSTEM
  • Sayfa Sayısı: ss.107-116

Özet

Pediatric high-grade gliomas (pHGGs) constitute almost 15% of all childhood brain tumors. Recurrent mutations such as H3K27M mutation in H3F3A and HIST1H3B genes encoding histone H3 and its variants were identified in approximately 30% of pediatric glioblastomas. This study aimed to ascertain the morphological and molecular characteristics of pHGGs with H3K27M mutation.