Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors

BOZKURT S., DAĞÇINAR A., TANRIKULU B., Comunoglu N., Meydan B. C., ÖZEK Ö. M. M., ...More

CHILDS NERVOUS SYSTEM, vol.34, no.1, pp.107-116, 2018 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1007/s00381-017-3633-5
  • Journal Name: CHILDS NERVOUS SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.107-116
  • Keywords: ATRX, p53, Histomorphology, BRAF V600E, INTRINSIC PONTINE GLIOMAS, THERAPEUTIC IMPLICATIONS, GLIONEURONAL TUMORS, GENETIC ALTERATIONS, K27M MUTATION, HISTONE H3.3, BRAF V600E, GLIOBLASTOMA, H3F3A, SUBGROUPS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Pediatric high-grade gliomas (pHGGs) constitute almost 15% of all childhood brain tumors. Recurrent mutations such as H3K27M mutation in H3F3A and HIST1H3B genes encoding histone H3 and its variants were identified in approximately 30% of pediatric glioblastomas. This study aimed to ascertain the morphological and molecular characteristics of pHGGs with H3K27M mutation.