Rapid detection of rifampin resistance in Mycobacterium tuberculosis isolates by heteroduplex analysis and determination of rifamycin cross-resistance in rifampin-resistant isolates
JOURNAL OF CLINICAL MICROBIOLOGY, vol.41, no.2, pp.816-818, 2003 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 41 Issue: 2
- Publication Date: 2003
- Doi Number: 10.1128/jcm.41.2.816-818.2003
- Journal Name: JOURNAL OF CLINICAL MICROBIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.816-818
- Acibadem Mehmet Ali Aydinlar University Affiliated: No
Abstract
Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish Mycobacterium tuberculosis isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.