Terminal phalangeal accessory ossification center of the thumb: an additional radiographic finding in Larsen syndrome
PEDIATRIC RADIOLOGY, vol.36, no.9, pp.970-973, 2006 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 36 Issue: 9
- Publication Date: 2006
- Doi Number: 10.1007/s00247-006-0217-z
- Journal Name: PEDIATRIC RADIOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.970-973
- Keywords: bifid thumb, accessory thumb ossification, Larsen syndrome, filamin B, DISLOCATIONS, FACIES
- Acibadem Mehmet Ali Aydinlar University Affiliated: No
Abstract
Larsen syndrome is an autosomal-dominant disorder characterized by multiple joint dislocations, vertebral anomalies and dysmorphic facies. Both autosomal-dominant and autosomal-recessive forms of the disorder have been proposed. Individuals with autosomal-dominant Larsen syndrome have characteristic "cylindrical-shape" thumbs caused by broad, shortened phalanges. Autosomal-dominant Larsen syndrome results from heterozygosity for mutations in filamin B, a cytoskeletal protein involved in multicellular processes. We report here a patient with a duplicated or accessory distal thumb phalanx and multiple large joint dislocations who was shown to be heterozygous for a filamin B mutation predicting the amino acid substitution G1691S. This adds a new radiographic finding, duplicated or accessory distal phalanx, to the radiographic abnormalities seen in this rare dominant disorder.