Adipose tissue gene expression of adiponectin, tumor necrosis factor-α and leptin in metabolic syndrome patients with coronary artery disease.

Gormez, SELÇUK; Demirkan, Ayse; ATALAR, Fatmahan; Caynak, Baris; Erdim, Refik; SÖZER, Volkan; Gunay, Demet; Akpinar, Bellhan; Ozbek, UĞUR; Buyukdevrim, Ahmet

doi:10.2169/internalmedicine.50.4753

Adipose tissue gene expression of adiponectin, tumor necrosis factor-α and leptin in metabolic syndrome patients with coronary artery disease.

Gormez S., Demirkan A., ATALAR F., Caynak B., Erdim R., SÖZER V., ...Daha Fazla

Internal medicine (Tokyo, Japan), cilt.50, sa.8, ss.805-10, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 50 Sayı: 8
Basım Tarihi: 2011
Doi Numarası: 10.2169/internalmedicine.50.4753
Dergi Adı: Internal medicine (Tokyo, Japan)
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.805-10
Anahtar Kelimeler: metabolic syndrome, atherosclerosis, chemokines, inflammation, genes, IN-VIVO, ADIPOCYTOKINES, PROTEIN, WEIGHT, RISK
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine organ secreting various adipocytokines. In the current study, adiponectin, tumor necrosis factor-alpha (TNF-alpha) and leptin gene expressions in the epicardial adipose tissue (EAT), paracardial adipose tissue (PAT) and subcutaneous adipose tissue (SAT) were investigated in MS patients with CAD and in non-MS patients without CAD.