Adipose tissue gene expression of adiponectin, tumor necrosis factor-α and leptin in metabolic syndrome patients with coronary artery disease.


Gormez S., Demirkan A., ATALAR F., Caynak B., Erdim R., SÖZER V., ...Daha Fazla

Internal medicine (Tokyo, Japan), cilt.50, sa.8, ss.805-10, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2169/internalmedicine.50.4753
  • Dergi Adı: Internal medicine (Tokyo, Japan)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.805-10
  • Anahtar Kelimeler: metabolic syndrome, atherosclerosis, chemokines, inflammation, genes, IN-VIVO, ADIPOCYTOKINES, PROTEIN, WEIGHT, RISK
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine organ secreting various adipocytokines. In the current study, adiponectin, tumor necrosis factor-alpha (TNF-alpha) and leptin gene expressions in the epicardial adipose tissue (EAT), paracardial adipose tissue (PAT) and subcutaneous adipose tissue (SAT) were investigated in MS patients with CAD and in non-MS patients without CAD.