Synthesis, characterization, and anticarcinogenic potent of green-synthesized zinc oxide nanoparticles via <i>Citrus aurantium</i> aqueous peel extract


Erdogan O., Pasa S., DEMİRBOLAT G. M., Birtekocak F., Abbak M., Cevik O.

INORGANIC AND NANO-METAL CHEMISTRY, cilt.55, sa.1, ss.67-75, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/24701556.2023.2240768
  • Dergi Adı: INORGANIC AND NANO-METAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.67-75
  • Anahtar Kelimeler: breast cancer, Citrus aurantium, Green synthesis, zinc oxide nanoparticles
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Synthesis of nanoparticles with a green approach using plants has attracted great attention from scientific communities because of its characteristics, such as environmentally friendly and time-efficient. In this study, green synthesis of zinc oxide nanoparticles was performed by Citrus aurantium aqueous peel extract. UV-VIS, FTIR, zeta potential, SEM, and EDX were used in characterization studies. In the UV-Vis spectrum, a heightening of the absorbance was monitored in the range of 260-390 nm specific to ZnO. The mean particle size of zinc oxide NPs (ZnONPs) was characterized as 632 & PLUSMN; 41 nm with low polydispersity (0.174 & PLUSMN; 0.055). As a result of EDX analysis, the presence of Zn in the scanned area was determined as 2.32%. The cytotoxic behaviors of ZnONPs on human breast cancer cells (MDA-MB-231) were carried out by MTT method. It was discovered that after ZnONPs application, cell migration decreased and apoptotic cell rate increased with Hoescht/PI staining in MDA-MB-231 cells.