The crosstalk between H. pylori virulence factors and the PD1:PD-L1 immune checkpoint inhibitors in progression to gastric cancer


Aydin E. M. , Demir T. D. , Seymen N., Said S. S. , ÖKTEM OKULLU S. , TIFTIKCI A. , ...More

IMMUNOLOGY LETTERS, vol.239, pp.1-11, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 239
  • Publication Date: 2021
  • Doi Number: 10.1016/j.imlet.2021.06.009
  • Title of Journal : IMMUNOLOGY LETTERS
  • Page Numbers: pp.1-11
  • Keywords: Helicobacter pylori, Immune checkpoint inhibitors, T-Lymphocytes, Stomach neoplasms, Ulcer, Gastritis, REGULATORY T-CELLS, NEUTROPHIL-ACTIVATING PROTEIN, HELICOBACTER-PYLORI, VACUOLATING CYTOTOXIN, EPITHELIAL-CELLS, VACA GENOTYPES, EXPRESSION, IMMUNIZATION, INFECTION, RESPONSES

Abstract

Background: The progression to gastric cancer has been linked to chronic infection with Helicobacter pylori (H. pylori). Immune checkpoint inhibitors (programmed cell death -1, PD-1; programmed cell death -ligand 1, PD-L1) have a role in cancer immune escape. The relationship between H. pylori virulence factors with PD-1, PD-L1 T helper 1 (Th1), T helper 17 (Th17), and regulatory T cell (Treg) response genes, has not been thoroughly investigated in the development of gastric cancer. Therefore, we evaluated how H. pylori virulence factors influence the expression levels of immune-related genes in the development of gastric immunopathology.