INFLUENCE OF PIRENZEPINE ON GALLBLADDER CONTRACTION IN MAN INDUCED BY SHAM FEEDING OR AN INTRADUODENAL MEAL


TANKURT E., YEGEN B., BIREN T., GURMEN N., ONAT F. , ERCIL A., ...Daha Fazla

DIGESTION, cilt.51, sa.2, ss.103-109, 1992 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Konu: 2
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1159/000200883
  • Dergi Adı: DIGESTION
  • Sayfa Sayıları: ss.103-109

Özet

Pirenzepine, an M1 muscarinic receptor antagonist, was tested for its ability to antagonize sham feeding- and intraduodenal fatty meal-stimulated gallbladder contraction in man. Intravenously administered pirenzepine abolished sham feeding-induced gallbladder contraction. Pirenzepine also inhibited contraction induced by intraduodenal meal, but this inhibition was of a lesser magnitude than the inhibition of sham feeding-induced contraction. The results demonstrate that the cephalic phase of gallbladder contraction is probably mediated by M1 muscarinic receptors while the duodenal phase of gallbladder contraction is partially mediated by M1 receptors.