Dysregulation of the DKK1 gene in pediatric B-cell acute lymphoblastic leukemia


Firtina S., Hatirnaz Ng Ö. , Erbilgin Y., Ozbek U. , Sayitoglu M.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.1, pp.357-363, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1507-106
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.357-363

Abstract

Background/aim: The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the beta-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation results in abnormal WNT activation. The secreted inhibitor Dickkopf can antagonize WNT signaling by competitively binding to low density lipoprotein receptors (LRPs) 5 and 6.