Insulin-Like Growth Factor-1 Levels in Twins and Its Correlation With Discordance

Canpolat F. E., Cekmez F., Sarici S. U., Korkmaz A., Yurdakok M.

TWIN RESEARCH AND HUMAN GENETICS, cilt.14, sa.1, ss.94-97, 2011 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1375/twin.14.1.94
  • Dergi Adı: TWIN RESEARCH AND HUMAN GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.94-97
  • Anahtar Kelimeler: IGF-1, discordance, twin, fetal growth, POSTNATAL-GROWTH, BIRTH-WEIGHT, INTRAUTERINE GROWTH, BINDING PROTEIN-1, CORD BLOOD, IGF-II, TERM
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

This study aims to determine whether fetal growth is related to insulin-like growth factor-1 in dichorionic and monochorionic twins and also aims to investigate the correlation of insulin-like growth factor-1 to birthweight discordance in twins. We studied 100 women with twin pregnancies. The correlation tests of 36 discordant twins (15 monochorionic, 21 dichorionic) showed correlation between insulin-like growth factor-1 difference and birthweight discordance (insulin-like growth factor-1 vs. birthweight of first twin, r = +0.915, at 0.01 level, IGF-1 vs birthweight of second twin r = +0.790, at 0.01 level). In 49 monochorionic twins, independent of discordance, there was a correlation between birthweight discordance and insulin-like growth factor-1 difference (r = .538, at the 0.01 level). This correlation was not significant in dichorionic twins, r = .144, p = .01. These data suggest that growth discordances of twins exposed to the same maternal environment may be due to variations in IGF-1, depending upon the genetic similarity.