Akademik Veri Yönetim Sistemi
ARCHIVES OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.2, sa.3, ss.66-70, 2017 (Hakemli Dergi)
Aim: Urotensin II (UII) and its system is implicated in the etiology of many diseases
(including diabetes mellitus). We tried in this study to evaluate and compare UII levels in
gestational diabetes mellitus (GDM).
Methods: Thirty-six pregnant women (15 non-GDM patients consisted group 1 and 21
GDM patients consisted group 2) enrolled in this study. The 3rd group consisted of age
matched 22 non pregnant healthy women. Plasma UII levels were determined at the
beginning of the study. After 12 weeks of delivery, a second plasma UII was determined
from group 1 and 2.
Results: Gestational UII levels of both GDM and non-GDM patients were higher than
non-pregnant healthy controls (p=0.0001 for both). Both gestational and postpartum UII
levels of GDM patients were higher than non-GDM patients but had not reached
statistical significance (P≥0.05). Plasma UII concentrations in non-GDM patients
significantly decreased after delivery but not in GDM patients (p=0.036 and p≥0.05,
respectively)
Conclusions: The finding of elevated gestational plasma UII concentrations in GDM
patients which did not decrease significantly after delivery (in compare to non-GDM
patients) shows that plasma UII levels may have a