Investigation of changes in vWF expression in rabbit carotid artery collar model

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ARUN M. Z., Sevin G., YETİK ANACAK G. Y., Gonen Korkmaz C., Ustunes L.

IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, cilt.8, sa.1, ss.37-42, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5222/buchd.2018.037
  • Dergi Adı: IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.37-42
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective: Placement of a soft silicone collar around the carotid arteries of rabbits induces intimal thickening which is considered as one of the crucial steps in the development of atherosclerosis. In this study we aimed to investigate vWF expression levels on days 7 and 14 after collar placement.& para;& para;Methods: A soft inert silicon collar was placed around the left carotid artery for 7 and 14 days. vWF expression was investigated by quantitave RT-PCR. In each artery (collar or sham) cross-sectional areas of intima, media were measured and intima/ media ratio was calculated.& para;& para;Results: Intimal thickening was more pronounced on day 14 compared to day 7. However the collar caused increase in vWF expression which was found to be at the same level on days 7 and 14.& para;& para;Conclusion: Our findings emphasize the importance of vWF in collar-induced intimal thickening.