Akademik Veri Yönetim Sistemi
17th International Primary Care Diabetes Europe Conference , Barcelona, İspanya, 6 - 08 Haziran 2024, ss.26-27, (Özet Bildiri)
Diabetes Prevalence in Screen-Detected Active Tuberculosis cases: A case-control study conducted with a Point Of Care Test Pınar Topsever1 , Eda Yaldırak1 , Sesin Kocagöz3, Tanıl Kocagöz2, ACU Family Medicine Research Steering Group1 1 Acibadem Mehmet Ali Aydınlar University School of Medicine, Dept. of Family Medicine, 2 Acibadem Mehmet Ali Aydınlar University School of Medicine, Dept of Clinical Microbiology, 3 Acibadem Mehmet Ali Aydınlar University School of Medicine, Department of Infectious Diseases Aim(s) or purpose: The risk of TB in DM being threefold and suspectedly bi-directional, demonstrates a multimorbid pattern, thus, screening for either condition in both diseases may be beneficial. To facilitate 27 prevention in primary care (PC) care, Point-of-Care Tests (POCT) should be non-invasive, easy to administer, and yield quick, valid results. WHO recommended a POCT for PC to detect Mycobacterium tuberculosis antigen (MTB) in urine specimens, which had low sensitivity (6-20%) in the immune-competent average risk general population. On the other hand, sample concentration methods have been shown to increase the sensitivity of tests. The aim is to compare diabetes frequency in people with or without active TB and to test performance of a concentrated urine specimen POCT for TB in the primary care setting. Design and method: This case-control study will recruit its TB (+) cases from a Sanatorium confirmed by the gold standard test mycobacterial culture by Löwenstein-Jensen medium. Average risk, asymptomatic (no fever and no productive cough for ≥ 2 weeks) individuals applying to 9 academic residency training family health units will be enrolled as TB(-) controls. Concentrated urine samples of all cases and controls will be screened with the TB POCT. In order to exclude TB(+) in the PC sample, except for the POCT TB test, a subset of the control group will be validated for being active TB negative with the gold standard test. Cases and controls will be compared regarding the presence of type 2 DM (verified by ICD-10 codes and/or receiving diabetes medication). In order to detect a two-fold increase (26%) in anticipated diabetes cases (13.5% crude prevalence in the general population) between the two groups (power 80%, significance 0.05), the sample size is 290 participants (145 individuals per group). Results: NA Conclusions: Identifying an association of DM and TB and to test the performance of a POCT for urine samples to detect TB in primary care