Choline potentiates the pressor response evoked by glycyl-glutamine or naloxone in haemorrhaged rats

Gurun M., Millington W., Ulus İ. H.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.30, no.9, pp.640-642, 2003 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 9
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1440-1681.2003.03886.x
  • Journal Name: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.640-642
  • Keywords: choline, cholinergic system, glycyl-glutamine, Gly-Gln, haemorrhage, hypotension, opioid, ACETYLCHOLINE TURNOVER, MORPHINE, SHOCK, PHYSOSTIGMINE, REVERSAL, DEPRESSION, ANTAGONISM, ENDORPHIN, DECREASE, BRAIN
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

1. Severe blood loss initially lowers arterial pressure through a central mechanism that is thought to involve opioid and cholinergic neurons. The present study tested the hypothesis that simultaneous administration of a cholinergic agonist and an opioid receptor antagonist would produce a synergistic effect in the treatment of haemorrhage. Specifically, we tested whether choline, a precursor of acetylcholine, potentiates the pressor effect of the beta-endorphin derived peptide glycylglutamine (Gly-Gln) or the opioid receptor antagonist naloxone following acute haemorrhage.