ONCEL, D., OMEN, I, BiLGE, O., TEKANT, Y., ACARLI, K., ALPER, A., EMRE, A. and ARIOGUL, O. Bile Duct Injury during Cholecystectonty Requiring Delayed Liver Transplantation: A Case Report and Literature Review. Tohoku J. Exp. Med., 2006, 209 (4), 355-359 - Major bile duct injury during cholecystectomy represents potentially severe complications with unpredictable long-term results. If these lesions are not treated adequately, they can lead to hepatic failure or secondary biliary cirrhosis therefore requiring liver transplantation. We report a patient who required liver transplantation 15 years after open cholecystectomy. A 10-year old girl underwent open cholecystectomy and duodenal repair for cholelithiasis and cholecystoduodenal fistula. She required two surgical inteventions, hepaticojejunostomy which was performed in another center and portoenterostomy for biliary stricture at our institution seven years after the cholecystectomy. Eight years after the third operation, she required recurrent hospitalization for treatment of hepatic abscesses. The extremely short intervals between the three life threatening episodes and the rapid progression to severe sepsis were taken into consideration and liver transplantation was performed at the age of 25. She is leading a healthy life at 4 years post transplantation. Although iatrogenic biliary injury can usually be treated successfully by a combination of surgery, radiological and endoscopic techniques, patients with severe injuries develop irreversible liver disease. This case report and review of the literature suggest that liver transplantation is a treatment modality for a selected group of patients with end-stae liver disease secondary to bile duct injury. - bile duct injury; secondary biliary cirrhosis; liver transplantation (c) 2006 Tohoku University Medical Press.