Intraoperative magnetic resonance spectroscopy for identification of residual tumor during low-grade glioma surgery Clinical article

Pamir M. N., ÖZDUMAN K., Yildiz E., Sav A., Dincer A.

JOURNAL OF NEUROSURGERY, vol.118, no.6, pp.1191-1198, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.3171/2013.1.jns111561
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1191-1198
  • Keywords: 3-T intraoperative magnetic resonance imaging, low-grade glioma, magnetic resonance spectroscopy, oncology, MR-SPECTROSCOPY, BRAIN-TUMORS, RESECTION, DISTINCTION, EXTENT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Object. The authors had previously shown that 3-T intraoperative MRI (ioMRI) detects residual tumor tissue during low-grade glioma and that it helps to increase the extent of resection. In a proportion of their cases, however, the ioMRI disclosed T2-hyperintense areas at the tumor resection border after the initial resection attempt and prompted a differential diagnosis between residual tumor and nontumoral changes. To guide this differential diagnosis the authors used intraoperative long-TE single-voxel proton MR spectroscopy (ioMRS) and tested the correlation of these findings with findings from pathological examination of resected tissue.