Synthesis and Antibacterial Evaluation of Novel Benzimidazole, Benzothiazole, Benzofurane, and Naphtofurane Derivatives of Aminothiazoles Aminotiyazollerin Benzimidazol, Benzotiyazol, Benzofuran ve Naftofuran Türevlerinden Yeni Bileşiklerin Sentezi Ve Antimikrobiyal Etkilerinin Değerlendirilmesi

Şahin Z., Tok B. I., Akgün E., ÖZ A., YURTTAŞ L., Berk B., ...Daha Fazla

Fabad Journal of Pharmaceutical Sciences, cilt.47, sa.2, ss.231-240, 2022 (Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.55262/fabadeczacilik.1134587
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.231-240
  • Anahtar Kelimeler: aminothiazole, antibacterial, benzofurane, benzothiazole, naphtofurane
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, new compounds containing thiazole and benzimidazole/benzothiazole/benzofurane/naphtofurane rings were synthesized, and their antimicrobial effects were evaluated. 9 compounds were synthesized by converting the seconder and cyclic amines to thiourea, and continued by thiazole ring closure. Ring closure was achieved by methylene-carbonyl condensation except conventional methods. Compound characterization was realized by FT-IR, 1H NMR and 13C NMR and HRMS. Compounds did not show significant activity on bacterial strains. Nine aminothiazole derivatives have been synthesized successfully. Compounds did not show important antibacterial activity and thus were evaluated as inactive.