Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells.

Le H. H., Cinaroglu S. S., Manalo E. C., Ors A., Gomes M. M., Duan Sahbaz B., ...Daha Fazla

EBioMedicine, cilt.73, ss.103646, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.ebiom.2021.103646
  • Dergi Adı: EBioMedicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.103646
  • Anahtar Kelimeler: Senolytic, FOXO4, TP53, Cancer, PROTEIN SECONDARY STRUCTURE, CIRCULAR-DICHROISM SPECTRA, D-AMINO-ACID, CELLULAR SENESCENCE, WEB SERVER, INHIBITOR, COMPLEX, TRIFLUOROETHANOL, VALIDATION, PREDICTION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many different age-related diseases in mice. Cancer is an age-associated disease and there are numerous mechanisms driving cellular senescence in cancer that can be detrimental to recovery. Thus, it would be beneficial to develop a senolytic that acts not only on ageing cells but also senescent cancer cells to prevent cancer recurrence or progression.