Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells.

Le, Hillary; Cinaroglu, Suleyman; Manalo, Elise; Ors, Aysegul; Gomes, Michelle; Duan Sahbaz, Burcin; Bonic, Karla; Origel Marmolejo, Carlos; Quentel, Arnaud; Plaut, Justin; Kawashima, Taryn; Ozdemir, E; Malhotra, Sanjay; Ahiska, Yavuz; Sezerman, OSMAN; Bayram Akcapinar, GÜNSELİ; Saldivar, Joshua; Timucin, EMEL; Fischer, Jared

doi:10.1016/j.ebiom.2021.103646

Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells.

Le H. H., Cinaroglu S. S., Manalo E. C., Ors A., Gomes M. M., Duan Sahbaz B., ...Daha Fazla

EBioMedicine, cilt.73, ss.103646, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 73
Basım Tarihi: 2021
Doi Numarası: 10.1016/j.ebiom.2021.103646
Dergi Adı: EBioMedicine
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
Sayfa Sayıları: ss.103646
Anahtar Kelimeler: Senolytic, FOXO4, TP53, Cancer, PROTEIN SECONDARY STRUCTURE, CIRCULAR-DICHROISM SPECTRA, D-AMINO-ACID, CELLULAR SENESCENCE, WEB SERVER, INHIBITOR, COMPLEX, TRIFLUOROETHANOL, VALIDATION, PREDICTION
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many different age-related diseases in mice. Cancer is an age-associated disease and there are numerous mechanisms driving cellular senescence in cancer that can be detrimental to recovery. Thus, it would be beneficial to develop a senolytic that acts not only on ageing cells but also senescent cancer cells to prevent cancer recurrence or progression.