Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells.


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Le H. H. , Cinaroglu S. S. , Manalo E. C. , Ors A., Gomes M. M. , Duan Sahbaz B., ...More

EBioMedicine, vol.73, pp.103646, 2021 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73
  • Publication Date: 2021
  • Doi Number: 10.1016/j.ebiom.2021.103646
  • Title of Journal : EBioMedicine
  • Page Numbers: pp.103646
  • Keywords: Senolytic, FOXO4, TP53, Cancer, PROTEIN SECONDARY STRUCTURE, CIRCULAR-DICHROISM SPECTRA, D-AMINO-ACID, CELLULAR SENESCENCE, WEB SERVER, INHIBITOR, COMPLEX, TRIFLUOROETHANOL, VALIDATION, PREDICTION

Abstract

Background: Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many different age-related diseases in mice. Cancer is an age-associated disease and there are numerous mechanisms driving cellular senescence in cancer that can be detrimental to recovery. Thus, it would be beneficial to develop a senolytic that acts not only on ageing cells but also senescent cancer cells to prevent cancer recurrence or progression.