Akademik Veri Yönetim Sistemi
TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY, cilt.25, sa.1, ss.1-10, 2010 (ESCI, Scopus)
OBJECTIVES We evaluated the results of patients with gastric carcinoma who were treated with postoperative chemoradiotherapy. METHODS Seventy-six patients with gastric carcinoma, treated with postoperative chemoradiotherapy between 2003 and 2007, were retrospectively evaluated. There were 57 males. The median age was 55.5 years (34-73 years). Chemotherapy was given in accordance with the Intergroup-0116 study. Total 45Gy radiotherapy was delivered to the gastric bed and regional nodes and >50Gy dose was given to patients with positive surgical margins. Thirty-five patients were treated with 3-dimensional conformal radiotherapy. RESULTS Median survival was 22.5 months (6-60 months). The 5-year overall survival rate was 42%. Loco-regional failures and distant metastasis were detected in 10.5% and 34.2% of patients, respectively. Grade-3 acute toxicity was seen in 11 patients. No Grade-4 acute toxicity was detected. CONCLUSION Chemoradiotherapy improved loco-regional control rather than reduction of distant metastases. Lower incidence of acute toxicity might be due to nearly half of our patients being treated with conformal radiotherapy or to genetic differences in the patient population.