Association of clinicopathological features with E-cadherin (CDH1) gene-160 C > A promoter polymorphism in Turkish colorectal cancer patients

Bahadir A., Eral G., Budak M., Shimamoto F., Korpinar M. A., Erdamar S., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.15, sa.1, ss.26-31, 2019 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4103/jcrt.jcrt_1277_16
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.26-31
  • Anahtar Kelimeler: Clinicopathological features, colorectal cancer, E-cadherin (CDH1)-160 C > A polymorphism, polymerase chain reaction-restriction fragment length polymorphism analysis, susceptibility, SINGLE NUCLEOTIDE POLYMORPHISM, CYCLIN D1 CCND1, RISK, ADHESION, EXPRESSION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background and Aim of Study: The role of E-cadherin (CDH1) gene-160 C>A (rsl 6260) promoter polymorphism in colorectal cancer (CRC) still remains inconclusive. The aim of this study is to investigate the associations between the CDH1 -160 C>A polymorphism with the susceptibility and clinicopathological development of CRC in the Turkish patients. To our knowledge, this is the first report examining the role of CDH1 polymorphism in Turkish CRC patients.