Role of Inflammation in Pancreatic Cancer


Erkan M. M.

Inflammation and Cancer, Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta, Editör, Springer Nature, Basel, ss.129-151, 2014

  • Yayın Türü: Kitapta Bölüm / Mesleki Kitap
  • Basım Tarihi: 2014
  • Yayınevi: Springer Nature
  • Basıldığı Şehir: Basel
  • Sayfa Sayıları: ss.129-151
  • Editörler: Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta, Editör
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an extremely poor prognosis. Inflammatory processes have emerged as key mediators of pancreatic cancer development and progression. In genetically engineered mouse models, induction of pancreatitis accelerates PDAC development, and patients with chronic pancreatitis are known to have a higher risk of developing pancreatic cancer. In recent years, much effort has been given to identify the underlying mechanisms that contribute to inflammation-induced tumorigenesis. Many inflammatory pathways have been identified and inhibitors have been developed in order to prevent cancer development and progression. In this chapter, we discuss the role of inflammatory pathways in the initiation and progression of pancreatic cancer as well as the role of inhibitors used in treatment and prevention of pancreatic cancer.