Clinical management of a challenging malignancy, osteoblastoma-like osteosarcoma: a report of four cases and a review of the literature

Ozger H., Alpan B. , Soylemez M. S. , ÖZKAN K., SALDUZ A., Bilgic B., ...Daha Fazla

THERAPEUTICS AND CLINICAL RISK MANAGEMENT, cilt.12, ss.1261-1270, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 12
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2147/tcrm.s102966
  • Sayfa Sayıları: ss.1261-1270


Osteoblastoma-like osteosarcoma, a rare form of osteosarcoma, is a malignant lesion associated with risks of both local recurrence and distant metastasis. The differential diagnosis of osteoblastoma-like osteosarcoma from osteoblastoma and aggressive osteoblastoma remains controversial and challenging. Previous studies suggest that these three types of tumor are distinct entities. However, working out a precise diagnosis may not always be possible immediately on the basis of initial clinical, radiological, and histopathological features. On the other hand, the importance of a correct diagnosis cannot be overemphasized since the treatment strategies change dramatically according to the nature of the lesion. In all of our cases, initial Tru-Cut biopsies revealed osteoblastic features with minimal atypia, but further biopsies confirmed malignancy. A high index of suspicion and considerable experience are prerequisites for accurate diagnosis in case of clinicopathological and radiological discordance.