Akademik Veri Yönetim Sistemi
21st International Headache Congress, Seoul, Güney Kore, 14 - 17 Eylül 2023, ss.114
Objective: Misophonia is characterized by a negative
emotional response, such as anxiety, irritability, or restlessness, towards certain sounds, including but not limited
to tapping, chewing, typing, breathing, swallowing, or foot
tapping. Phonophobia is a subtype of misophonia characterized by fear as the dominant emotion. However, misophonia is characterized by other dominant emotions, such
as irritation, stress and anxiety, aggravation, feeling
trapped, and impatience.
Migraine is often associated with other neurological and
psychiatric disorders such as depression, and anxiety.
These comorbid conditions can significantly impact the
frequency, severity, and duration of migraine attacks, as
well as the response to treatment. Phonophobia may be
related to both ictal and interictal phases of migraine.
However, misophonia has not been studied in migraine
yet. The aim of this study was to investigate whether
misophonia is more prevalent in patients with migraine
compared to healthy individuals. Additionally, we aimed
to explore the association between misophonia and
migraine-related disability, depression, anxiety, stress
levels, and obsessive-compulsive traits.
Methods: We recruited 205 patients with migraine as a
migraine group (MG) and 205 healthy subjects as a control
group (CG). Demographics, Headache Impact Test-6
(HIT-6), Depression Anxiety Stress Scale (DASS-21),
Misophonia Scale (total score and severity scale), Yale
Brown Obsessive Compulsive Scale (Y-BOCS) were
recorded from all participants. In the MG, clinical features
of migraine, Migraine Disability Assessment Test (MIDAS)
and Allodynia Symptom Checklist were also obtained.
Results: The mean age [36.5 (9.5) vs. 36.5 (10.1);
p ¼ 0.956] and gender distributions were similar between
the MG and the CG. In the MG, the mean duration of
migraine was 14.1 years and the mean number of headache
days in the last month was 8.6 (6.7) days. The mean
MIDAS score was found to be 19.1 (21.5). In the MG,
22.4% of the patients had chronic migraine.
The percentage of patients exceeding the Misophonia
Severity Scale cut-off level (3
7) was found to be higher in
the MG than the CG (44.9% vs. 17.6%, p < 0.001). The
MG showed higher levels of interictal photophobia (53.7%
vs. 37.6%, p < 0.001), interictal phonophobia (67.3% vs.
36.6%, p < 0.001), and interictal osmophobia (49.8% vs.
41.0%, p > 0.001) compared to the CG.
The MG also showed statistical difference in the HIT-6
scores [65.2 (6.4) vs. 42.9 (6); p > 0.001], the mean
depression scores of DASS-21 [5.2 (4.7) vs. 3.93(3.5);
p > 0.001], the mean anxiety scores of DASS-21 [4.6
(3.9) vs. 2.9 (2.8); p > 0.001], the mean stress scores of
DASS-21 [7.8 (4.4) vs. 5.4 (3.5); p > 0.001], the
Misophonia Scale total scores [34.7 (15.1) vs. 21.4
(13.7); p > 0.001] and the Misophonia Scale severity
scores [6.7 (3.2) vs. 4.1 (2.5); p > 0.001] compared to
the CG. No difference was observed in the mean Y114 Cephalalgia 43(1S)
! International Headache Society 2023
BOCS scores [11.3 (9.0) vs. 9.4 (8.3); p ¼ 0.317] between
the two groups.
Conclusion: In our cohort, misophonia was more
common in migraine patients compared to healthy controls. Besides, misophonia showed a positive correlation
to the duration of migraine, depression, anxiety, stress
levels and obsessive-compulsive traits in the MG.
Therefore, it is recommended to consider misophonia
when evaluating comorbidity in migraine patients. Future
studies will reveal the relationship between migraine and
misophonia and its effect on the course of migraine.