Relationship between Endometrial Thickness and In Vitro Fertilization Intracytoplasmic Sperm Injection Outcome


international journal of fertility & sterility, vol.7, no.1, pp.29-34, 2013 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 1
  • Publication Date: 2013
  • Journal Name: international journal of fertility & sterility
  • Page Numbers: pp.29-34
  • Keywords: Endometrial Thickness, IVF-ICSI, Pregnancy Rate
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Background: This study assessed the relationship between endometrial thickness on human

chorionic gonadotropin (hCG) day and in vitro fertilization-intracytoplasmic sperm

injection (IVF-ICSI).

Materials and Methods: This prospective cross-sectional study included a total of 593

women. Patients were treated with either the agonist or antagonist protocol according to the

clinician’s and patient’s preference. Endometrial thickness on the hCG day was measured

by transvaginal ultrasonography (TV USG). Patients were divided into four groups according

to endometrial lines, as follows: <7 mm (group 1), 7-10 mm (group 2), 10-14 mm

(group 3), and >14 mm (group 4).

Results: Implantation rate (IR), clinical pregnancy rate (CPR), and ongoing pregnancy

rate (OPR) were significantly lower in group 1 than the other three groups (p<0.05).

However, there was no significant difference among groups 2, 3 and 4. Although the

endometrial line in the agonist protocol was higher than in the antagonist protocol, the

difference was not statistically significant.

Conclusion: There is a correlation between endometrial thickness and CPR only in the

group 1 that is less than the other groups. IVF-ICSI outcome is negatively influenced

when the endometrial line is below 7 mm.