Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization

Edupuganti, Om; Antoci, Valentin; King, Samuel; Jose, Binoy; Adams, Christopher; Parvizi, JAVAD; Shapiro, Irving; Zeiger, Allen; Hickok, Noreen; Wickstrom, Eric

doi:10.1016/j.bmcl.2007.03.005

Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization

Edupuganti O. P., Antoci V., King S. B., Jose B., Adams C. S., Parvizi J., ...More

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.17, no.10, pp.2692-2696, 2007 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 17 Issue: 10
Publication Date: 2007
Doi Number: 10.1016/j.bmcl.2007.03.005
Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2692-2696
Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Self-protecting Ti6A14V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6A14V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6A14V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. (c) 2007 Elsevier Ltd. All rights reserved.