Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.17, sa.10, ss.2692-2696, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 10
- Basım Tarihi: 2007
- Doi Numarası: 10.1016/j.bmcl.2007.03.005
- Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2692-2696
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Self-protecting Ti6A14V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6A14V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6A14V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. (c) 2007 Elsevier Ltd. All rights reserved.