Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of <i>Staphylococcus aureus</i> colonization

Edupuganti, Om; Antoci, Valentin; King, Samuel; Jose, Binoy; Adams, Christopher; Parvizi, JAVAD; Shapiro, Irving; Zeiger, Allen; Hickok, Noreen; Wickstrom, Eric

doi:10.1016/j.bmcl.2007.03.005

Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of <i>Staphylococcus aureus</i> colonization

Atıf İçin Kopyala

Edupuganti O. P., Antoci V., King S. B., Jose B., Adams C. S., Parvizi J., ...Daha Fazla

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.17, sa.10, ss.2692-2696, 2007 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 10
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.bmcl.2007.03.005
Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2692-2696
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Self-protecting Ti6A14V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6A14V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6A14V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models. (c) 2007 Elsevier Ltd. All rights reserved.