Mycophenolate mofetil as a novel immunosuppressant in the treatment of neuro-Behcet's disease with parenchymal involvement: presentation of four cases


Shugaiv E., Tuzun E., Mutlu M., Kiyat-Atamer A., Kurtuncu M., Akman-Demir G.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, cilt.29, 2011 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 29 Konu: 4
  • Basım Tarihi: 2011
  • Dergi Adı: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Özet

Background. Behcet's disease is a inultisystemic, relapsing, inflammatory disorder of unknown origin. Among Turkish cohorts, 5-15% of patients show involvement of the central nervous system (CNS) at some time during their disease. There, are mainly two types of clinical presentation: parehchymal CNS inflammation manifesting mainly as meningoencephalitis of the brainstem, or dural sinus thrombosis. Several drugs like high-dose steroids or immunosuppressive agents, mainly azathioprine, are used in the treatment. For patients who do not respond sufficiently to these agents or are not able tolerate them, other options are needed.