Pain mechanisms in chronic pancreatitis: of a master and his fire


Demir I. E. , Tieftrunk E., Maak M., Friess H., Ceyhan G.

LANGENBECKS ARCHIVES OF SURGERY, vol.396, no.2, pp.151-160, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 396 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1007/s00423-010-0731-1
  • Title of Journal : LANGENBECKS ARCHIVES OF SURGERY
  • Page Numbers: pp.151-160

Abstract

Unraveling the mechanisms of pain in chronic pancreatitis (CP) remains a true challenge. The rapid development of pancreatic surgery in the twentieth century, usage of advanced molecular biological techniques, and emergence of clinician-scientists have enabled the elucidation of several mechanisms that lead to the chronic, complicated neuropathic pain syndrome in CP. However, the proper analysis of pain in CP should include three main arms of mechanisms: "peripheral nociception," "peripheral/pancreatic neuropathy and neuroplasticity," and "central neuropathy and neuroplasticity."