LANGENBECKS ARCHIVES OF SURGERY, vol.396, no.2, pp.151-160, 2011 (Journal Indexed in SCI)
Article / Review
Title of Journal :
LANGENBECKS ARCHIVES OF SURGERY
Chronic pancreatitis, Pain, Peripheral pancreatic neuropathy, Neural remodeling, Sensitization, Temporal summation, EEG, Spinal hyperactivity, PYLORUS-PRESERVING WHIPPLE, CELIAC PLEXUS BLOCK, SUBSTANTIA-GELATINOSA NEURONS, NERVE GROWTH-FACTOR, NEUROPATHIC PAIN, SENSORY NEURONS, HEAD RESECTION, ELECTROPHYSIOLOGICAL PROPERTIES, RANDOMIZED-TRIAL, FOLLOW-UP
Unraveling the mechanisms of pain in chronic pancreatitis (CP) remains a true challenge. The rapid development of pancreatic surgery in the twentieth century, usage of advanced molecular biological techniques, and emergence of clinician-scientists have enabled the elucidation of several mechanisms that lead to the chronic, complicated neuropathic pain syndrome in CP. However, the proper analysis of pain in CP should include three main arms of mechanisms: "peripheral nociception," "peripheral/pancreatic neuropathy and neuroplasticity," and "central neuropathy and neuroplasticity."