The effect of propofol and thiopentone on impairment by reactive oxygen species of endothelium-dependent relaxation in rat aortic rings


Kelicen P., Ismailoglu U., Erdemli O. , SahinErdemli I.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, cilt.14, ss.310-315, 1997 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 14 Konu: 3
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1046/j.1365-2346.1997.00110.x
  • Dergi Adı: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
  • Sayfa Sayıları: ss.310-315

Özet

The effect in isolated rat aorta of propofol, thiopentone, midazolam, etomidate and fentanyl on the impairment of endothelium-dependent relaxation by reactive oxygen species is reported. Aortic rings were exposed to reactive oxygen species by the electrolysis of the bathing physiological buffer, and endothelium-dependent relaxation in response to acetylcholine was inhibited. This inhibition was countered by incubation before electrolysis with propofol (2 x 10(-5) and 6 x 10(-5) M) or thiopentone (10(-5)-10(-4) M), but not with midazolam (3 x 10(-4) M), etomidate (3 x 10(-4) M) or fentanyl (3 x 10(-5) M). We suggest that the protective effect of propofol and thiopentone against the loss of endothelium-dependent relaxation caused by reactive oxygen species may be because of their antioxidant and free radical scavenging properties, which could be clinically relevant during surgical procedures in which ischaemia is unavoidable.