Serum M65 as a biomarker for metastatic renal cell carcinoma.

YILDIZ İ., Sen F., Kilic L., Keskin S., DURANYILDIZ H. D., Bilgin E., ...More

Clinical genitourinary cancer, vol.11, no.3, pp.290-6, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.clgc.2013.01.001
  • Journal Name: Clinical genitourinary cancer
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.290-6
  • Keywords: Serum M65 level, Apoptosis, Cytokeratin 18, Kidney cancer, Prognostic factors, CASPASE-CLEAVED CYTOKERATIN-18, LUNG-CANCER, MONOCLONAL-ANTIBODIES, DEATH, M30, REORGANIZATION, FRAGMENTS, DIAGNOSIS, ANTIGENS, PRODUCT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

We aimed to investigate the prognostic significance of M30 and M65 which are biomarkers of apoptotic cell death in renal cell cancer (RCC). Serum levels of M30 and M65 were analyzed in 39 consecutively enrolled patients with metastatic RCC and control subjects using enzyme-linked immunosorbent assay (ELISA) kits. We found that high serum M65 levels might predict worse outcome resulting in shorter progression-free survival in RCC.