Prognostic value of p53, proliferating cell nuclear antigen, and Ki-67 expression in undifferentiated nasopharyngeal carcinomas

Genc E., Hosal A., Gedikoglu G., Ozyar E. , Sozeri B.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, cilt.122, ss.868-873, 2000 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 122 Konu: 6
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0194-5998(00)70016-7
  • Sayfa Sayıları: ss.868-873


In this study the prognostic importance of p53, proliferating cell nuclear antigen (PCNA), and Ki-67 expression was analyzed along with the clinical parameters in 35 consecutive patients with undifferentiated nasopharyngeal carcinomas. Immunohistochemistry was used to detect p53, PCNA, and Ki-67 staining. Among the clinical findings, stage IV disease (P = 0.01), cranial nerve paralysis (P = 0.02), and lymph node metastasis (P = 0.06) were associated with shorter survival. The p53 positivity correlated with the presence of lymph nodes, but it was not a significant factor to predict the outcome. PCNA expression was not found to be a prognostic indicator, On the other hand, the proliferative value of Ki-67 staining was suggestive of prognosis. A proliferation index of Ki-67 less than 10% indicated longer survival (P = 0.03). There was no correlation between Ki-67 staining and PCNA index. As a result, the prognostic value of Ki-67 may alert the physician to more aggressive and adjuvant treatment modalities.