Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy

Gurun M., Savci V., Ulus İ. H.

JOURNAL OF AUTONOMIC PHARMACOLOGY, cilt.17, sa.3, ss.155-163, 1997 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1046/j.1365-2680.1997.00450.x
  • Dergi Adı: JOURNAL OF AUTONOMIC PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.155-163
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

1 The effect of centrally administered choline on blood pressure was investigated in rats made hypotensive by chemical sympathectomy. Chemical sympathectomy was produced by intravenous (i.v.) injection of 50 mg kg(-1) of 6-hydroxydopamine (6-OHDA). Intracerebroventricular (i.c.v.) administration of choline (50-150 mu g) 2 h after 6-OHDA treatment increased blood pressure and reversed the hypotension in a dose-dependent mariner without affecting heart rate. The presser response was associated with an increase in plasma vasopressin levels.