Background and design: Statins are lipid-lowering drugs inhibiting an early step of cholesterole biosynthesis. They may lead skin changes by affecting lipid components of the skin. In this study effects of Pravastatin therapy on the skin of 27 patients with hypercholesterolemia is reported. Results: Pruritus, xerosis and plantar hyperkeratosis were observed in 9, 2 and 2 patients, respectively. No such effects were observed in the rest. Conclusion: Lipid-lowering drug usage should be kept in mind while investigating aetiology of chronic pruritus.