World Congress of Gastroenterology, İstanbul, Türkiye, 21 - 24 Eylül 2019, cilt.30, ss.490
The impact of serum mean platelet volume in chronic peptic ulcer disease
Cem Aygün1, Nigar Rustemova2, Aysun Bozbaş1, Nesliar Eser Kutsal1, Nurdan Tozun1
1Department of Gastroenterology, Acıbadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey
2Department of Internal Medicine, Acıbadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey
Background/Aims: Peptic ulcer disease (PUD) represents defects in gastrointestinal mucosa that may extent through the muscularis
mucosa into deeper layers of the gastric or intestinal wall. Usually it is chronic, benign and located in stomach or proximal duodenum. Symptoms of chronic PUD are not specific and therefore have limited predictive value in diagnosis. Patients with chronic PUD, especially elderly patients, may be asymptomatic or have only mild symptoms. Mean platelet volume (MPV) is accepted as a representative laboratory indicator of platelet function and activation. Over the past few decades, a considerable numbers of studies have investigated the associations between MPV with several diseases. In this study we aimed to evaluate the impact of MPV on endoscopically” diagnosed chronic PUD patients and compare this data with healthy individuals.
Materials and Methods: This study retrospectively evaluated the hospital records of 120 patients with chronic PUD who underwent upper gastrointestinal endoscopic examination in our gastroenterology clinics. Exclusion criteria included previous
surgery for peptic ulcer disease, esophageal ulcer, gastric cancer, severe systemic diseases such as diabetes mellitus, hypertension, cardiovascular diseases, liver and kidney diseases, myeloproliferative disorders, leukaemia and Bernard-Soulier Syndrome. A control group was formed including 120 healthy individuals who had compatible ages and sexes and were found to be in good health as a result of a check-up procedure. Demographic features and complete blood count with MPV were recorded for all participants. Age, leukocyte, hemoglobin, platelet count and MPV were compared between the two groups.
Results: The data showed that mean platelet count was significantly higher in the PUD group compared with the control group (p=0.04). However, the mean MPV was significantly lower in the PUD group when compared with the control group (p<0.001). There were no significant differences in mean age, sex, hemoglobin and leukocyte counts between the two groups. According to the ROC curve analysis performed for the prediction of chronic PUD in the study, the best cut-off point for the MPV was 10.1 fl (sensitivity 68%, specificity 87.3%, area under curve [AUC]:0.8). There was no correlation between MPV with hemoglobin or leukocyte counts but there was a negative correlation between MPV and platelet counts (r=-0.2966, p=0.0024).
Conclusion: Our study results revealed that mean platelet count is increased but MPV is decreased in chronic PUD patients as compared to controls. Complete blood count is a cheap and easily accessible test. Although MPV is a routine component of complete blood count, it is often overlooked. Interpretation of MPV levels in chronic PUD patients may be a useful marker in assessment of the disease and future folow-up. According to our results low MPV can be a unique and an important additional
risk factor as well.
Keywords: Mean platelet volume, platelets, peptic ulcer disease