Corticosteroid therapy augments gastroduodenal permeability to sucrose.


Kiziltaş Ş. , Imeryüz N., Gürcan T., Siva A., Saip S., Dumankar A., ...More

The American journal of gastroenterology, vol.93, pp.2420-5, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 93
  • Publication Date: 1998
  • Doi Number: 10.1111/j.1572-0241.1998.00697.x
  • Title of Journal : The American journal of gastroenterology
  • Page Numbers: pp.2420-5

Abstract

Şafak Kızıltaş, Neşe İmeryüz, Türcan Gürcan, Aksel Sıva, Sabahattin Saip, Ali Dumankar, Cem Kalaycı, Nefise B Ulusoy
Yayın tarihi
1998/12/1
Dergi
The American journal of gastroenterology
Cilt
93
Sayı
12
Sayfalar
2420-2425
Yayıncı
No longer published by Elsevier
Açıklama
Objective: The aim of the present study was to investigate whether corticosteroid therapy alters gastroduodenal mucosal permeability and whether permeability alteration is associated with macroscopic mucosal damage. Methods: Eight patients taking oral corticosteroid therapy (total prednisone-equivalent dose, 1.5 ± 0.1 g; duration, ∼30 days), nine patients with multiple sclerosis taking high-dose intravenous methyl-prednisolone therapy (total dose, 11.7 ± 0.5 g; duration, ∼9 days), and 20 age- and gender-matched controls were studied. Gastroduodenal permeability was determined using sucrose as a site-specific permeability probe. Five-hour urine was collected after ingesting 100 g of sucrose and its urinary excretion rate was measured using high-pressure liquid chromatography. Gastroduodenal endoscopy was performed before steroid therapy to exclude subjects with evidence of macroscopic mucosal …
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Ş Kızıltaş, N İmeryüz, T Gürcan, A Sıva, S Saip… - The American journal of gastroenterology, 1998