TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.32, ss.72-75, 2007 (SCI İndekslerine Giren Dergi)
The aim of this study was to investigate whether serum uric acid levels increase in Diabetes Mellitus and if serum uric acid levels were related to factors apart from hypertension and renal failure. Fifty-five newly diagnosed patients with type 2 Diabetes Mellitus and 41 healthy volunteers were included in the study. Serum creatinin level, total cholesterol level, low density lipoprotein-cholesterol level, body mass index, age, and arterial blood pressure was not different in diabetic group, when compared with the control group. However, serum uric acid level (4.6 +/- 1.5 mg/dL) was significantly lower than those of the control group (5.3 +/- 1.7 mg/dL) (p<0.05). In addition, uric acid in the diabetic group did not significantly correlate with the biochemical and clinical variables, whereas in the control group, serum uric acid level was significantly correlated with systolic blood pressure, diastolic blood pressure, fasting blood glucose level, hemoglobin A(1C) level and body mass index. We think that decreased serum uric acid level in diabetes is dependent on many factors. In addition, the decrease of serum uric acid level may be contributed to oxidative stress in diabetes.