Increased Soluble Selectins as a Reflection of Activated Platelets and Endothelium in Legg-Calve-Perthes Disease


Ismayilov V., Aksoy D. Y. , SAYINALP N., Haznedarog I. C. , AKSOY M. C.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.36, 2014 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 36 Konu: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1097/mph.0000000000000203
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Özet

Background and Aim: Legg-Calve-Perthes disease (LCPD) is still an enigma. Hemostatic abnormalities have been indicated in the pathogenesis. We had previously demonstrated enhanced tissue factor pathway inhibitor response, increased global fibrinolytic capacity, and an increase in thrombomodulin in patients with LCPD compared with healthy individuals. These studies emphasized the role of vascular endothelium in pathogenesis of the LCPD. P-selectin is expressed on activated platelets and endothelial cells, and E-selectin is expressed on activated endothelial cells. The aim of this study was to assess circulating E-selectin and P-selectin levels in LCPD patients, which might reflect an endothelium activation and/or injury.