Advanced oxidation protein products and ischaemia-modified albumin in obstructive sleep apnea


Ozben S., Huseyinoglu N. , Hanikoglu F., Guvenc T. S. , Yildirim B. Z. , Cort A., ...More

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol.44, no.11, pp.1045-1052, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 11
  • Publication Date: 2014
  • Doi Number: 10.1111/eci.12338
  • Title of Journal : EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
  • Page Numbers: pp.1045-1052

Abstract

BackgroundSeveral studies have shown that obstructive sleep apnea increases incidence of cardiovascular morbidity and mortality. The high systemic oxidative stress in obstructive sleep apnea has been considered as a major pathogenic mechanism leading to cardiovascular disease. Oxidative stress-related lipid and DNA oxidation in obstructive sleep apnea have been reported in the previous studies. In contrast, there is limited and contradictory information regarding protein oxidation in obstructive sleep apnea patients such as ischaemia-modified albumin and advanced oxidation protein products. Therefore, we aimed to investigate plasma ischaemia-modified albumin and advanced oxidation protein products and their correlation with total oxidative status and total antioxidative capacity in the obstructive sleep apnea patients.