Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties


Alpugan S., Topkaya D., Atilla D., Ahsen V., Niazi J. H. , DUMOULIN F.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, vol.21, no.12, pp.887-892, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1142/s1088424617500973
  • Title of Journal : JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Page Numbers: pp.887-892

Abstract

Tetrasulfonated Zn phthalocyanine was conjugated to a ssDNA aptamer moiety to produce a HER2 targeted photosensitizer. The tetraconjugate obtained was subjected to purification and the monoconjugate was successfully isolated, purified and characterized. This monoconjugate retained the ability to bind to HER2 as well as the potency to generate singlet oxygen.