Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties

Alpugan S., TOPKAYA TAŞKIRAN D., ATİLLA D., AHSEN V., Niazi J. H., DUMOULIN F.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, cilt.21, sa.12, ss.887-892, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1142/s1088424617500973
  • Dergi Adı: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.887-892
  • Anahtar Kelimeler: cancer targeting, photodynamic therapy, HER2, aptamer, phthalocyanine, PHOTOSENSITIZER, DELIVERY, SELEX, ACID
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Tetrasulfonated Zn phthalocyanine was conjugated to a ssDNA aptamer moiety to produce a HER2 targeted photosensitizer. The tetraconjugate obtained was subjected to purification and the monoconjugate was successfully isolated, purified and characterized. This monoconjugate retained the ability to bind to HER2 as well as the potency to generate singlet oxygen.