Diagnosis of Periprosthetic Infection: Recent Developments
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, vol.102, no.15, pp.1366-1375, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 102 Issue: 15
- Publication Date: 2020
- Doi Number: 10.2106/jbjs.19.00598
- Journal Name: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Public Affairs Index, SportDiscus, Veterinary Science Database
- Page Numbers: pp.1366-1375
- Acibadem Mehmet Ali Aydinlar University Affiliated: No
Abstract
There is no absolute test for the preoperative diagnosis of periprosthetic joint infection (PJI); thus, clinical practice relies on a combination of supportive tests and criteria.Novel serum and synovial tests have improved our ability to diagnose PJI. The 2018 evidence-based algorithm for PJI diagnosis provides weighted scores for serum markers, as well as synovial markers, to facilitate diagnosis when major criteria such as positive cultures or a sinus tract are not present.Culture-independent technologies such as next-generation sequencing can facilitate pathogen identification, particularly in the setting of culture-negative PJI.Despite recent developments, PJI diagnosis remains challenging and warrants further innovation.