Takotsubo syndrome (TS) has been described as an acute cardiac condition precipitated by a stressful mental or physical condition. A majority of patients are presented with acute substernal chest pain. It is often difficult to differentiate TS from acute ST-elevation myocardial infarction (STEMI) on initial presentation. The electrocardiograph classically mimics STEMI and is generally accompanied by elevation of myocardial enzymes that warrants immediate cardiac catheterization. The present article reports a patient with TS referred to the emergency department because of symptoms suggestive of acute coronary syndrome.