Cloning and expression profile of FLT3 gene during progenitor cell-dependent liver regeneration


Aydin I. T. , Tokcaer Z. , Dalgic A., Konu O., Akcali K. C.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.22, ss.2181-2188, 2007 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 22 Konu: 12
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1440-1746.2006.04731.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Sayfa Sayısı: ss.2181-2188

Özet

Background and Aim: The liver has a unique capacity to regenerate upon exposure to viral infections, toxic reactions and cancer formation. Liver regeneration is a complex phenomenon in which several factors participate during its onset. Cellular proliferation is an important component of this process and the factors that regulate this proliferation have a vital role. FLT3, a well-known hematopoietic stem cell and hepatic lineage surface marker, is involved in proliferative events of hematopoietic stem cells. However, its contribution to liver regeneration is not known. Therefore, the aim of this study was to clone and examine the role of FLT3 during liver regeneration in rats.