Cyclotriphosphazene, a scaffold for F-19 MRI contrast agents

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Onal E., Zhang C., Davarci D., Isci U., Pilet G., Whittaker A. K., ...Daha Fazla

TETRAHEDRON LETTERS, cilt.59, sa.6, ss.521-523, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.tetlet.2017.12.032
  • Dergi Adı: TETRAHEDRON LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.521-523
  • Anahtar Kelimeler: F-19 MRI, Cyclotriphosphazene, Contrast agent, MAGNETIC-RESONANCE, DESIGN, DERIVATIVES, DENDRIMERS, COMPLEXES
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

A cyclotriphosphazene substituted with six 3,5-bis(trifluoromethyl) benzyloxy units was designed as a novel F-19 MRI contrast agent. The resulting molecule has 36 magnetically equivalent fluorine atoms and exhibited suitable MRI properties with high imaging sensitivity, confirming the proof-of-concept as a convenient scaffold for the production of new F-19 MRI contrasts agents. (C) 2017 Elsevier Ltd. All rights reserved.