Cyclotriphosphazene, a scaffold for F-19 MRI contrast agents

Onal E., Zhang C., Davarci D., Isci U., Pilet G., Whittaker A. K. , ...More

TETRAHEDRON LETTERS, vol.59, no.6, pp.521-523, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 6
  • Publication Date: 2018
  • Doi Number: 10.1016/j.tetlet.2017.12.032
  • Title of Journal : TETRAHEDRON LETTERS
  • Page Numbers: pp.521-523


A cyclotriphosphazene substituted with six 3,5-bis(trifluoromethyl) benzyloxy units was designed as a novel F-19 MRI contrast agent. The resulting molecule has 36 magnetically equivalent fluorine atoms and exhibited suitable MRI properties with high imaging sensitivity, confirming the proof-of-concept as a convenient scaffold for the production of new F-19 MRI contrasts agents. (C) 2017 Elsevier Ltd. All rights reserved.