Predictors of malignancy in surgically removed foot and ankle masses: a retrospective multi-center study


Kanay E., Bulut H., Tutuncu M. N., Batibay S., DEMİRÖZ S., Okay E., ...Daha Fazla

European Journal of Orthopaedic Surgery and Traumatology, cilt.35, sa.1, 2025 (ESCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s00590-025-04338-w
  • Dergi Adı: European Journal of Orthopaedic Surgery and Traumatology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Anahtar Kelimeler: Amputation, Foot and ankle tumors, Malignancy predictors, Orthopedic oncology, Recurrence
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Purpose: Foot and ankle masses, though uncommon, are an important subset of musculoskeletal tumors, encompassing benign and malignant forms. Malignant tumors often necessitate aggressive treatment, including amputation, and unplanned resections can worsen outcomes by increasing recurrence risk. Identifying predictors of malignancy and functional deficits is vital for improving treatment strategies. Methods: A retrospective review of 120 tumors in 112 patients (2017–2024) assessed demographics, tumor characteristics, size, surgical approach, and outcomes. Interventions included excision, curettage, and amputation, with reconstruction when needed. Predictors of malignancy and functional outcomes were statistically analyzed. Results: Malignancy was observed in 9.8% of cases, with tumor size > 45 mm and age > 45 years identified as significant predictors. The majority of surgeries were excisions (83.9%), followed by curettage in 13.3% and amputation in 2.8%. Complete resection (R0) was achieved in 94.5% of cases. Early-term (0–180 days) wound complications occurred in 5.4%, while late-term recurrence (median 22 months) was observed in 4.5% Conclusion: Tumor size and patient age are key malignancy predictors. Complete resection improves outcomes, highlighting the importance of tailored surgical planning.