The European Biological Variation Study (EuBIVAS): weekly biological variation of cardiac troponin I estimated by the use of two different high-sensitivity cardiac troponin I assays.

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Ceriotti F., Díaz-Garzón M., Fernández-Calle P., Maregnani A., Aarsand A., Coskun A., ...More

Clinical chemistry and laboratory medicine, vol.58, pp.1741-1747, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58
  • Publication Date: 2020
  • Doi Number: 10.1515/cclm-2019-1182
  • Journal Name: Clinical chemistry and laboratory medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1741-1747
  • Keywords: analytical performance specifications, biological variation, high-sensitivity cardiac troponin I, reference change value, EMERGENCY-DEPARTMENT PATIENTS, WITHIN-PERSON VARIATION, GENERAL-POPULATION, HEALTHY, RISK
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Background: Cardiac troponins (cTn) are specific markers for cardiac damage and acute coronary syndromes. The availability of new high-sensitivity assays allows cTn detection in healthy people, thus permitting the estimation of biological variation (BV) of cTn. The knowledge of BV is important to define analytical performance specifications (APS) and reference change values (RCVs). The aim of this study was to estimate the within- and between-subject weekly BV (CVI, CVG) of cTnI applying two high-sensitivity cTnI assays, using European Biological Variation Study (EuBIVAS) specimens.