Clinical chemistry and laboratory medicine, vol.58, pp.1741-1747, 2020 (SCI-Expanded)
Article / Article
Clinical chemistry and laboratory medicine
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
analytical performance specifications, biological variation, high-sensitivity cardiac troponin I, reference change value, EMERGENCY-DEPARTMENT PATIENTS, WITHIN-PERSON VARIATION, GENERAL-POPULATION, HEALTHY, RISK
Acibadem Mehmet Ali Aydinlar University Affiliated:
Background: Cardiac troponins (cTn) are specific markers for cardiac damage and acute coronary syndromes. The availability of new high-sensitivity assays allows cTn detection in healthy people, thus permitting the estimation of biological variation (BV) of cTn. The knowledge of BV is important to define analytical performance specifications (APS) and reference change values (RCVs). The aim of this study was to estimate the within- and between-subject weekly BV (CVI, CVG) of cTnI applying two high-sensitivity cTnI assays, using European Biological Variation Study (EuBIVAS) specimens.