The European Biological Variation Study (EuBIVAS): weekly biological variation of cardiac troponin I estimated by the use of two different high-sensitivity cardiac troponin I assays.

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Ceriotti F., Díaz-Garzón M., Fernández-Calle P., Maregnani A., Aarsand A., Coskun A., ...Daha Fazla

Clinical chemistry and laboratory medicine, cilt.58, ss.1741-1747, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/cclm-2019-1182
  • Dergi Adı: Clinical chemistry and laboratory medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1741-1747
  • Anahtar Kelimeler: analytical performance specifications, biological variation, high-sensitivity cardiac troponin I, reference change value, EMERGENCY-DEPARTMENT PATIENTS, WITHIN-PERSON VARIATION, GENERAL-POPULATION, HEALTHY, RISK
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Cardiac troponins (cTn) are specific markers for cardiac damage and acute coronary syndromes. The availability of new high-sensitivity assays allows cTn detection in healthy people, thus permitting the estimation of biological variation (BV) of cTn. The knowledge of BV is important to define analytical performance specifications (APS) and reference change values (RCVs). The aim of this study was to estimate the within- and between-subject weekly BV (CVI, CVG) of cTnI applying two high-sensitivity cTnI assays, using European Biological Variation Study (EuBIVAS) specimens.