Effects of Ozone on Spinal Cord Recovery via the Wnt/ Β-Catenin Pathway Following Spinal Cord Injury in Rats.

Tural Emon S., Uslu S., Ilgaz Aydinlar E., Irban A., İNCE Ü., Orakdogen M., ...More

Turkish neurosurgery, vol.27, no.6, pp.946-951, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.5137/1019-5149.jtn.17508-16.1
  • Journal Name: Turkish neurosurgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.946-951
  • Keywords: Beta-catenin, Ozone therapy, Rat, Spinal cord injury, Wnt pathway, THERAPY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

AIM: At the cellular level, spinal cord injury (SCI) provokes an inflammatory response that generates substantial secondary damage within the spinal cord but may also contribute to its repair. Besides intracellular antioxydant increase after exactly estimated oxidative stress; oxygen formation and transport is also advanced by ozone. The Wnt family of proteins contributes to the development of the nervous system, influencing cell proliferation. In the present study we evaluated the effect of ozone on spinal cord injury in rats.